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Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh3)2-μ-dmoPTA-1κP:2k2N,N'-CoCl2]OTf·0.25H2O are described. The stability of the complex was studied under air and N2 atmospheres and in CDCl3, DMSO,… Click to show full abstract
Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh3)2-μ-dmoPTA-1κP:2k2N,N'-CoCl2]OTf·0.25H2O are described. The stability of the complex was studied under air and N2 atmospheres and in CDCl3, DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh3)2(HdmoPTA)]2+ against human lung, cervix, breast, and colon solid tumor cell lines.
Journal Title: Dalton transactions
Year Published: 2017
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