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An unprecedented and challenging simultaneous carboxylation/halogenation, and next lactonization of γ,γ-dicarbonyl-substituted aldehydes has been realized using an eco-friendly, safe and inexpensive solid sodium chlorite (NaClO2)/1,3-dibromo-5,5-dimethyl-hydantoin (DBDMH) combination. This new reaction… Click to show full abstract
An unprecedented and challenging simultaneous carboxylation/halogenation, and next lactonization of γ,γ-dicarbonyl-substituted aldehydes has been realized using an eco-friendly, safe and inexpensive solid sodium chlorite (NaClO2)/1,3-dibromo-5,5-dimethyl-hydantoin (DBDMH) combination. This new reaction is amenable to a multi-gram scale-up with high yield.
Keywords:
dicarbonyl substituted;
dbdmh combination;
substituted aldehydes;
sodium chlorite
Journal Title: Green Chemistry
Year Published: 2017
Link to full text (if available)
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Journal Title: Green Chemistry
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!