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An efficient approach for the synthesis of 5-hydroxy-chromeno[2,3-b]pyridines under catalyst and solvent free conditions

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An efficient and sustainable method has been developed for the synthesis of novel 5-hydroxy-chromeno[2,3-b]pyridines by the reaction of 3-formylchromone, aromatic amines and malononitrile under catalyst and solvent-free conditions by simply… Click to show full abstract

An efficient and sustainable method has been developed for the synthesis of novel 5-hydroxy-chromeno[2,3-b]pyridines by the reaction of 3-formylchromone, aromatic amines and malononitrile under catalyst and solvent-free conditions by simply stirring the components magnetically or by grinding at room temperature. Excellent yields, environmentally benign reaction conditions and easy workup are the advantages of this protocol. The structures have been established unambiguously.

Keywords: free conditions; catalyst solvent; chromeno pyridines; solvent free; hydroxy chromeno; synthesis

Journal Title: Green Chemistry
Year Published: 2017

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