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An efficient and practical aerobic benzylic sp3 C–H oxidation as a key step towards the domino multi-component synthesis of 2,4,5-trisubstituted imidazoles has been reported. This green methodology employs an inexpensive… Click to show full abstract
An efficient and practical aerobic benzylic sp3 C–H oxidation as a key step towards the domino multi-component synthesis of 2,4,5-trisubstituted imidazoles has been reported. This green methodology employs an inexpensive catalytic copper/oxygen system and proceeds under mild reaction conditions. A variety of substituted imidazoles are prepared in moderate to excellent yields from α-methylene ketones using this innovative methodology.
Keywords:
methodology;
aerobic benzylic;
multi component;
domino multi;
sp3 oxidation;
benzylic sp3
Journal Title: Green Chemistry
Year Published: 2017
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Journal Title: Green Chemistry
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!