A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column… Click to show full abstract
A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani. The most active compounds were assayed as potential TcCYP51 inhibitors.
Keywords:
antitrypanosomal antileishmanial;
prenyl triazoles;
activity prenyl;
prenyl;
antileishmanial activity
Journal Title: MedChemComm
Year Published: 2017
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Journal Title: MedChemComm
Year Published: 2017
Link to full text (if available)
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recommendations!