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“A Jack of Trio”-robust one-pot metal free oxidative amination, azidation and peroxidation of phenols

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Herein we disclose a highly efficient methodology for the generation of nitrogen containing quaternary carbon centres via aminative and azidative oxidative dearomatization of phenols. The same protocol has also been… Click to show full abstract

Herein we disclose a highly efficient methodology for the generation of nitrogen containing quaternary carbon centres via aminative and azidative oxidative dearomatization of phenols. The same protocol has also been successfully employed to achieve oxidative peroxidation of phenols. The simplest metal free reaction conditions delineate an easy breakthrough to the “Trio”- oxidative amination, azidation and peroxidation. An array of diverse polyfunctionalised heterocycles has been synthesized in one pot.

Keywords: peroxidation phenols; oxidative amination; azidation peroxidation; peroxidation; metal free; amination azidation

Journal Title: New Journal of Chemistry
Year Published: 2017

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