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A transition metal-free and hypervalent iodine-promoted annulative aminocyanation of unactivated alkenes has been developed for the first time. This regioselective 5-exo-trig process provides a concise method to synthesize diversely substituted… Click to show full abstract
A transition metal-free and hypervalent iodine-promoted annulative aminocyanation of unactivated alkenes has been developed for the first time. This regioselective 5-exo-trig process provides a concise method to synthesize diversely substituted cyanated pyrrolidine, piperidine and indoline derivatives under mild reaction conditions with up to 80% yield, in which the cyanated position of the double bond is controlled by different hypervalent iodine regents.
Keywords:
hypervalent iodine;
intramolecular aminocyanation;
alkenes promoted;
iodine;
aminocyanation alkenes
Journal Title: Organic chemistry frontiers
Year Published: 2017
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Journal Title: Organic chemistry frontiers
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!