An efficient method for the synthesis of C2-spiropseudoindoxyls which are common structural units prevalent in indole alkaloids was developed. A study of the mechanism indicated that this protocol involved a… Click to show full abstract
An efficient method for the synthesis of C2-spiropseudoindoxyls which are common structural units prevalent in indole alkaloids was developed. A study of the mechanism indicated that this protocol involved a Pd-catalyzed 5-exo-dig nitroalkyne cyclization and an internal N–O bond redox process. The fungicidal activity evaluation of representative compounds highlighted this reaction for the construction of bioactive functionalized spiro-heterocycles.
Keywords:
catalyzed cycloisomerization;
efficient method;
method synthesis;
spiro
Journal Title: Organic chemistry frontiers
Year Published: 2017
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Journal Title: Organic chemistry frontiers
Year Published: 2017
Link to full text (if available)
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recommendations!