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A palladium/nickel catalyzed selective N–H/C–H methylation of amides by using peroxides is described, providing N-methylation products and C-methylation products in moderate to good yields. In this procedure, peroxides play a… Click to show full abstract
A palladium/nickel catalyzed selective N–H/C–H methylation of amides by using peroxides is described, providing N-methylation products and C-methylation products in moderate to good yields. In this procedure, peroxides play a dual role, serving as both the methyl source and radical initiator. This protocol tolerated a broad range of substrates, not only various sulfonamides but also methanamides. Mechanistic investigations involving a radical process are also described.
Keywords:
methylation;
catalyzed selective;
using peroxides;
methylation amides;
amides using;
selective methylation
Journal Title: Organic chemistry frontiers
Year Published: 2017
Link to full text (if available)
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Journal Title: Organic chemistry frontiers
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!