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An efficient copper-catalyzed α-C–H amidation of simple ethers with N-(8-quinolyl)amides through C(sp3)–H/N–H cross dehydrogenative coupling was developed. Chelation assistance was employed for the formation of an active copper amide species… Click to show full abstract
An efficient copper-catalyzed α-C–H amidation of simple ethers with N-(8-quinolyl)amides through C(sp3)–H/N–H cross dehydrogenative coupling was developed. Chelation assistance was employed for the formation of an active copper amide species which can couple with the α-carbon-centered radical generated from simple ethers. This method was applicable to both alkyl and aryl amides as well as various cyclic and acyclic ethers. It also possessed the merit of air and moisture tolerance.
Journal Title: Organic chemistry frontiers
Year Published: 2018
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