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Homodimericin A is a fascinating fungal metabolite and a highly oxygenated cage-like polyketide. A practical total synthesis of homodimericin A has been achieved in 7 steps. The synthesis features a… Click to show full abstract
Homodimericin A is a fascinating fungal metabolite and a highly oxygenated cage-like polyketide. A practical total synthesis of homodimericin A has been achieved in 7 steps. The synthesis features a basic aqueous buffer promoted dimerization of quinone monomers, a thermal intramolecular Diels–Alder reaction and a carbonyl–ene cyclization cascade.
Keywords:
synthesis homodimericin;
chemistry;
homodimericin;
total synthesis;
biomimetic total;
synthesis
Journal Title: Organic chemistry frontiers
Year Published: 2018
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Journal Title: Organic chemistry frontiers
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!