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A protocol for the direct synthesis of 5-aryloxazole-4-carbonitrile from acetophenone was first described with potassium ferricyanide as a cheap and low toxicity cyanide reagent, in which, multiple bond formation was… Click to show full abstract
A protocol for the direct synthesis of 5-aryloxazole-4-carbonitrile from acetophenone was first described with potassium ferricyanide as a cheap and low toxicity cyanide reagent, in which, multiple bond formation was implemented via an oxygen mediated radical mechanism. Potassium ferricyanide played a dual role as a “CN” source and also as a coupling partner for the cyclization of oxazole.
Keywords:
mediated formation;
copper mediated;
carbonitrile;
carbonitrile acetophenone
Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
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Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
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recommendations!