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Eleven new phthalide derivatives (1–11) have been isolated from the rhizome of Ligusticum chuanxiong. In particular, 1 and 2 contain a mercaptopropionic acid moiety in the phthalide derivatives. All the… Click to show full abstract
Eleven new phthalide derivatives (1–11) have been isolated from the rhizome of Ligusticum chuanxiong. In particular, 1 and 2 contain a mercaptopropionic acid moiety in the phthalide derivatives. All the structures, including their absolute configurations, were determined by UV, IR, HRESIMS, 1D and 2D NMR spectroscopic measurements, and by a comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Results of a bioassay showed that compound 4 has a moderate neuroprotective activity on human neuroblastoma SH-SY5Y cell injury induced by H2O2 and oxygen glucose deprivation (OGD).
Journal Title: RSC Advances
Year Published: 2017
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