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The Src SH2 domain was synthesized via native chemical ligation of two fragment peptides. The facile protocol was used to prepare the mirror-image SH2 domain (D-Src SH2 domain) and tetramethylrhodamine-labeled… Click to show full abstract
The Src SH2 domain was synthesized via native chemical ligation of two fragment peptides. The facile protocol was used to prepare the mirror-image SH2 domain (D-Src SH2 domain) and tetramethylrhodamine-labeled SH2 domains. The synthesized SH2 domains were correctly folded and showed activity, and using these proteins we established bioassays to identify novel Src SH2 domain inhibitors from an unexplored mirror-image library of natural products.
Keywords:
sh2 domain;
mirror image;
sh2;
src sh2
Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
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Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
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recommendations!