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We have developed a protocol for the auxillary directed C–H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and… Click to show full abstract
We have developed a protocol for the auxillary directed C–H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone. The 2-pyridine group allows for a highly efficient palladium-catalyzed chlorination and sequential ortho C–H functionalization reaction of phenol derivatives to produce a variety of symmetrical and unsymmetrical 2,4,6-trisubstituted phenols.
Keywords:
phenol derivatives;
late stage;
chlorination;
stage chlorination
Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
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Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!