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A new and facile approach to 1,2-dihydroisoquinolin-3(4H)-imines by the Cu(I)-catalyzed reaction of 2-ethynylbenzyl methanesulfonates, sulfonyl azides and amines

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A new, step-economical and operationally simple access to unsubstituted 1,2-dihydroisoquinolin-3(4H)-imines by Cu-catalyzed MCRs under mild conditions is described. In addition, selective hydrolysis of imines to the corresponding 1,2-dihydroisoquinolin-3(4H)-ones under refluxed… Click to show full abstract

A new, step-economical and operationally simple access to unsubstituted 1,2-dihydroisoquinolin-3(4H)-imines by Cu-catalyzed MCRs under mild conditions is described. In addition, selective hydrolysis of imines to the corresponding 1,2-dihydroisoquinolin-3(4H)-ones under refluxed conc. HCl has also been investigated.

Keywords: dihydroisoquinolin imines; approach dihydroisoquinolin; dihydroisoquinolin; new facile; imines catalyzed; facile approach

Journal Title: RSC Advances
Year Published: 2018

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