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Traceless β-mercaptan-assisted activation of valinyl benzimidazolinones in peptide ligations† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04148a

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An internal activation strategy-enabled traceless ligation at sterically hindered Val-Xaa site is accomplished under thiol additive-free conditions assisted by a β-mercaptan on the C-terminal valine residue. Click to show full abstract

An internal activation strategy-enabled traceless ligation at sterically hindered Val-Xaa site is accomplished under thiol additive-free conditions assisted by a β-mercaptan on the C-terminal valine residue.

Keywords: activation valinyl; activation; traceless mercaptan; valinyl benzimidazolinones; assisted activation; mercaptan assisted

Journal Title: Chemical Science
Year Published: 2018

Link to full text (if available)


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