"Increasing the bioactive space of peptide macrocycles by thioamide substitution† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04671e"

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Increasing the bioactive space of peptide macrocycles by thioamide substitution† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04671e

Thioamide substitution into macrocyclic peptides increases the conformational rigidity of the backbone resulting in enhanced biological activity and metabolic stability. Click to show full abstract

Thioamide substitution into macrocyclic peptides increases the conformational rigidity of the backbone resulting in enhanced biological activity and metabolic stability.

Keywords: space peptide; peptide macrocycles; bioactive space; thioamide substitution; substitution; increasing bioactive

Journal Title: Chemical Science
Year Published: 2018

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