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Platelet-derived nanovesicles for hemostasis without release of pro-inflammatory cytokines.

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Natural platelet-derived nanovesicles with a vacant core were prepared by hypotonic sonication. The nanovesicles efficiently formed platelet-like aggregates using membrane protein in the presence of thrombin and calcium chloride without… Click to show full abstract

Natural platelet-derived nanovesicles with a vacant core were prepared by hypotonic sonication. The nanovesicles efficiently formed platelet-like aggregates using membrane protein in the presence of thrombin and calcium chloride without a notable release of pro-inflammatory cytokines. These natural and biocompatible platelet-derived nanovesicles have great potential as biomaterials for inflammation-free injectable hemostasis.

Keywords: inflammatory cytokines; derived nanovesicles; release pro; platelet derived; pro inflammatory

Journal Title: Biomaterials science
Year Published: 2019

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