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An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species.

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Herein, we developed a strategy to attack the cancer cell defense system against reactive oxygen species to improve photodynamic therapy efficacy with a Ce6@MSN@MTH1 siRNA nanosystem, which was demonstrated to… Click to show full abstract

Herein, we developed a strategy to attack the cancer cell defense system against reactive oxygen species to improve photodynamic therapy efficacy with a Ce6@MSN@MTH1 siRNA nanosystem, which was demonstrated to improve cellular sensitivity to reactive oxygen species through suppressing MTH1 protein in cancer cells.

Keywords: reactive oxygen; oxygen species; cellular sensitivity; sensitivity reactive; nanosystem

Journal Title: Chemical communications
Year Published: 2018

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