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We develop a triple-amplification strategy for sensitive detection of telomerase from cancer cells using telomere-based primer generation-triggered rolling circle amplification in combination with enzyme-assisted cyclic signal amplification. This method can… Click to show full abstract
We develop a triple-amplification strategy for sensitive detection of telomerase from cancer cells using telomere-based primer generation-triggered rolling circle amplification in combination with enzyme-assisted cyclic signal amplification. This method can detect telomerase at the single-cell level, and it can be further applied for the screening of telomerase inhibitors for anticancer drug discovery.
Keywords:
telomerase;
triple amplification;
strategy sensitive;
amplification strategy;
sensitive detection;
amplification
Journal Title: Chemical communications
Year Published: 2018
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!