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Ultrasensitive profiling of multiple biomarkers from single cells by signal amplification mass spectrometry.

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A signal amplification protocol based on mass spectrometry (MS) was developed to profile simultaneously multiple biomarkers from a single cell using various mass label (ML)-modified Au nanoparticles (AuNPs). The strategy… Click to show full abstract

A signal amplification protocol based on mass spectrometry (MS) was developed to profile simultaneously multiple biomarkers from a single cell using various mass label (ML)-modified Au nanoparticles (AuNPs). The strategy with ultrahigh sensitivity and specificity has potential prospects in the deep exploration of molecular and cellular characterization.

Keywords: mass spectrometry; multiple biomarkers; mass; biomarkers single; signal amplification

Journal Title: Chemical communications
Year Published: 2018

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