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WEPA: a bio-derived medium for added base, π-acid and ligand free Ullmann coupling of aryl halides using Pd(OAc)2.

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A bio-derived sustainable medium based on water extract of pomegranate ash (WEPA) has, for the first time, been developed for the homocoupling of aryl halides under palladium-assistance. Avoiding the requirement… Click to show full abstract

A bio-derived sustainable medium based on water extract of pomegranate ash (WEPA) has, for the first time, been developed for the homocoupling of aryl halides under palladium-assistance. Avoiding the requirement of an external base, ligand and π-acid, the use of the proposed renewable medium offers remarkable attributes like wide substrate scope, good to nearly quantitative yields of biphenyls with exceptional chemoselectivity and scale up viability.

Keywords: medium; base; aryl halides; bio derived

Journal Title: Chemical communications
Year Published: 2018

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