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One-step construction of molecular complexity by tert-butyl nitrite (TBN)-initiated cascade α,β-sp3 C-H bond difunctionalization and C-N bond cleavage.

TBN-initiated cascade multifunctionalization of inert C-H and C-N bonds in N-arylazacycles has been realized under transition-metal free conditions, in which the synthetically useful oxime, N-NO and aldehyde functional groups were… Click to show full abstract

TBN-initiated cascade multifunctionalization of inert C-H and C-N bonds in N-arylazacycles has been realized under transition-metal free conditions, in which the synthetically useful oxime, N-NO and aldehyde functional groups were constructed in only one synthetic step.

Keywords: bond; tbn initiated; one step; initiated cascade

Journal Title: Chemical communications
Year Published: 2018

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