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Templated synthesis of spherical RNA nanoparticles with gene silencing activity.

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RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles… Click to show full abstract

RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles that self-assemble into spherical nanoparticles in aqueous solution and show gene silencing activity.

Keywords: silencing activity; templated synthesis; rna; gene silencing

Journal Title: Chemical communications
Year Published: 2018

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