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Displacement chemistry-based nanopore analysis of nucleic acids in complicated matrices.

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To overcome the effect of other components of complicated biological samples on nanopore stochastic sensing, displacement chemical reaction was utilized to selectively extract the target nucleic acid from whole blood.… Click to show full abstract

To overcome the effect of other components of complicated biological samples on nanopore stochastic sensing, displacement chemical reaction was utilized to selectively extract the target nucleic acid from whole blood. Given its simplicity and high sensitivity for detecting nucleic acids, our developed displacement chemistry-based nanopore sensing strategy offers the potential for fieldable/point-of-care diagnostic applications.

Keywords: nucleic acids; chemistry; based nanopore; nanopore analysis; chemistry based; displacement chemistry

Journal Title: Chemical communications
Year Published: 2018

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