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Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis.

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We developed a ready-to-read on-bead peptide encoding method for high-throughput screening bioassays. With two-dimensional surface-enhanced Raman scattering nano-identifiers (2D-SERS IDs) which are concurrently labelled with two SERS codes (coupling steps… Click to show full abstract

We developed a ready-to-read on-bead peptide encoding method for high-throughput screening bioassays. With two-dimensional surface-enhanced Raman scattering nano-identifiers (2D-SERS IDs) which are concurrently labelled with two SERS codes (coupling steps and kinds of amino acid), we could possibly generate more than 10 trillion codes with only 30 Raman label compounds.

Keywords: encoding method; two dimensional; sers encoding; bead peptide; dimensional sers; high throughput

Journal Title: Chemical communications
Year Published: 2019

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