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Electrochemical synthesis of tetrazoles via metal- and oxidant-free [3 + 2] cycloaddition of azides with hydrazones

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An unprecedented electrochemical [3 + 2] cycloaddition reaction for the synthesis of valuable tetrazoles was developed. Readily available azides and hydrazones were used as the starting materials under simple metal-… Click to show full abstract

An unprecedented electrochemical [3 + 2] cycloaddition reaction for the synthesis of valuable tetrazoles was developed. Readily available azides and hydrazones were used as the starting materials under simple metal- and oxidant-free reaction conditions. Various functional groups are compatible with this green protocol which can be carried out on a gram-scale or in one pot easily.

Keywords: cycloaddition; metal oxidant; oxidant free; azides hydrazones; synthesis

Journal Title: Green Chemistry
Year Published: 2018

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