"Development of a method for the quantitative metabolite profiling of pharmaceutical drugs using HPLC-ICP-MS following pre-column derivatization of their amino and hydroxyl groups using 4-aminopyridine as a model compound"

LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Development of a method for the quantitative metabolite profiling of pharmaceutical drugs using HPLC-ICP-MS following pre-column derivatization of their amino and hydroxyl groups using 4-aminopyridine as a model compound

Presence of amino and/or hydroxyl groups allows for derivatization of APIs and their metabolites with 4-iodobenzoylchloride, thus enabling HPLC-ICP-MS metabolite profiling. Click to show full abstract

Presence of amino and/or hydroxyl groups allows for derivatization of APIs and their metabolites with 4-iodobenzoylchloride, thus enabling HPLC-ICP-MS metabolite profiling.

Keywords: metabolite profiling; amino hydroxyl; hydroxyl groups; hplc icp

Journal Title: Journal of Analytical Atomic Spectrometry
Year Published: 2019

Link to full text (if available)

Share on Social Media: Sign Up to like & get
recommendations!
0

LAUSR

You are not signed in:

Sign Up!

Related content

More Information News Social Media Video Recommended