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Hydroxyapatite (HA) was modified by the chelation of citric acid and Ca2+ on the surface of HA, followed by cross-linking between the hydroxyl groups of β-cyclodextrin (β-CD) and citrate, and… Click to show full abstract
Hydroxyapatite (HA) was modified by the chelation of citric acid and Ca2+ on the surface of HA, followed by cross-linking between the hydroxyl groups of β-cyclodextrin (β-CD) and citrate, and then further in situ ring-opening polymerization of L-lactide over the hydroxyl groups. The modification of HA adjusted its surface properties and reduced the particle size. The synthesized PLA-CD-HA-72 exhibited the good adhesion of mesenchymal stem cells (MSCs) of Wistar rats, higher viability of MSCs and larger osteoinductivity. The results indicated that the PLA-CD-HA-72 possessed a rather large biocompatibility and bioactivity, and it could be a promising candidate as a bone tissue engineering material.
Journal Title: New Journal of Chemistry
Year Published: 2018
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