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Metal-free hydrogen transfer reduction of 3-hydroxy-3-indolyloxindoles: a novel method for the synthesis of 3,3′-biindolin-2-ones

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Herein, a new approach for the synthesis of 3,3′-biindolin-2-ones is reported. The transformation has been successfully performed following a one-step strategy starting from 3-hydroxy-3-indolyloxindoles. The reaction proceeds smoothly under mild… Click to show full abstract

Herein, a new approach for the synthesis of 3,3′-biindolin-2-ones is reported. The transformation has been successfully performed following a one-step strategy starting from 3-hydroxy-3-indolyloxindoles. The reaction proceeds smoothly under mild conditions and is applicable to a broad scope of substrates. In this process, a number of products were obtained in good to excellent yields (≥99%) using Bronsted acid as a catalyst and benzothiazolines as the hydrogen source.

Keywords: hydroxy indolyloxindoles; synthesis biindolin; metal free; biindolin ones

Journal Title: New Journal of Chemistry
Year Published: 2018

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