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Activation of the catalytic function of formaldehyde dehydrogenase for formate reduction by single-electron reduced methylviologen

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The kinetic properties of formate reduction to formaldehyde with formaldehyde dehydrogenase (FldDH) using single-electron reduced methylviologen (MV˙) as a co-enzyme were clarified. By using natural co-enzyme NADH, actually, no formaldehyde… Click to show full abstract

The kinetic properties of formate reduction to formaldehyde with formaldehyde dehydrogenase (FldDH) using single-electron reduced methylviologen (MV˙) as a co-enzyme were clarified. By using natural co-enzyme NADH, actually, no formaldehyde production due to formate reduction with FldDH was observed. In contrast, we discovered that MV˙ activates the FldDH activity for formate reduction to formaldehyde for the first time.

Keywords: formate reduction; reduction; single electron; electron reduced; formaldehyde dehydrogenase

Journal Title: New Journal of Chemistry
Year Published: 2018

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