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NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: Synthesis of dihetaryl substituted alkenes

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An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1H-azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic,… Click to show full abstract

An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1H-azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1,1-dihaloalkenes containing functionalities such as nitriles, ethers, and halogens. Imidazoles and triazoles also afforded the desired products.

Keywords: dihetaryl substituted; dihaloalkenes azoles; naoh promoted; reaction; substituted alkenes; synthesis dihetaryl

Journal Title: New Journal of Chemistry
Year Published: 2018

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