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Two novel chiral cyclic peptide analogues of galaxamide were synthesized by photoinduced single electron transfer cyclization. Their stereochemistry was studied by experimental and theoretical ECD simulations. The title compounds were… Click to show full abstract
Two novel chiral cyclic peptide analogues of galaxamide were synthesized by photoinduced single electron transfer cyclization. Their stereochemistry was studied by experimental and theoretical ECD simulations. The title compounds were found to be active against HepG-2 cell lines (IC50 = 19.52 for 1 and 26.34 μg mL−1 for 2).
Keywords:
synthesis chiral;
chiral galaxamide;
induced synthesis;
photo induced;
analogs biological;
galaxamide analogs
Journal Title: New Journal of Chemistry
Year Published: 2018
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Journal Title: New Journal of Chemistry
Year Published: 2018
Link to full text (if available)
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recommendations!