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Fluorous interaction induced self-assembly of tobacco mosaic virus coat protein for cisplatin delivery.

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Tobacco mosaic virus coat protein was modified with a small molecular fluorous ponytail at specific sites, and self-assembled into spherical nanoparticles through fluorous interaction induced self-assembly. By loading the anti-cancer… Click to show full abstract

Tobacco mosaic virus coat protein was modified with a small molecular fluorous ponytail at specific sites, and self-assembled into spherical nanoparticles through fluorous interaction induced self-assembly. By loading the anti-cancer drug cisplatin through metal-ligand coordination, this spherical assembly with high stability has potential as a drug carrier.

Keywords: tobacco mosaic; mosaic virus; coat protein; virus coat; interaction induced; fluorous interaction

Journal Title: Nanoscale
Year Published: 2018

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