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Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

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Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition and surface chemistry… Click to show full abstract

Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition and surface chemistry where only the aspect-ratio is varied. PEGylated brush nanoparticles revealed that brush nanorods exhibit higher association and penetration into multicellular tumour spheroids compared to their spherical or filamentous counterparts.

Keywords: aspect ratio; chemistry; polymer brushes; polymer; multicellular tumour; molecular polymer

Journal Title: Polymer Chemistry
Year Published: 2018

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