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An efficient and green protocol for the synthesis of acylated imidazo[1,2-a]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed. The reaction proceeds smoothly utilizing I2 as a… Click to show full abstract
An efficient and green protocol for the synthesis of acylated imidazo[1,2-a]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed. The reaction proceeds smoothly utilizing I2 as a catalyst and TBHP as an oxidant with a broad substrate scope. Mechanism studies reveal that the reaction maybe experiences a hydration followed by an oxidative cycloamination process.
Keywords:
acylated imidazo;
dehydrogenative aminooxygenation;
aminooxygenation alkynes;
pyridines indolizines;
imidazo pyridines;
intramolecular dehydrogenative
Journal Title: Organic chemistry frontiers
Year Published: 2018
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Journal Title: Organic chemistry frontiers
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!