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The site-selective copper-catalyzed three-component coupling reaction of electron-deficient heterocycles, Se powder and aryl iodides is disclosed. The established methodology provides an efficient and practical pathway to access 2-arylselenated heterocycles via… Click to show full abstract
The site-selective copper-catalyzed three-component coupling reaction of electron-deficient heterocycles, Se powder and aryl iodides is disclosed. The established methodology provides an efficient and practical pathway to access 2-arylselenated heterocycles via copper-catalyzed double C–Se bond formation. This transformation features the use of elemental Se as the selenating reagent, a cost-effective catalytic system, and the late-stage selenation of bioactive compounds.
Journal Title: Organic chemistry frontiers
Year Published: 2018
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