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Oxindoles display a diverse pattern of reactivity upon reaction with different classes of amino alcohols via the borrowing hydrogen process. Whereas the reaction with N-acetyl amino alcohols leads to C3… Click to show full abstract
Oxindoles display a diverse pattern of reactivity upon reaction with different classes of amino alcohols via the borrowing hydrogen process. Whereas the reaction with N-acetyl amino alcohols leads to C3 alkylation, the reaction with N-alkyl amino alcohols results in the formation of synthetically useful α-aryl-lactams via a remarkably facile oxindole ring-opening reaction. Reactions occurred with quantitative conversion and selectivity under relatively mild reaction conditions.
Keywords:
via borrowing;
borrowing hydrogen;
amino alcohols;
reaction;
alcohols via
Journal Title: Organic chemistry frontiers
Year Published: 2018
Link to full text (if available)
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Journal Title: Organic chemistry frontiers
Year Published: 2018
Link to full text (if available)
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recommendations!