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Diverse anti-Markovnikov hydrofunctionalization of alkenols triggered by the addition of S-, P-, and C-centered radicals to alkenes followed by intramolecular 1,5(6)-hydrogen atom transfer (HAT) with remote α-C–H bonds of alcohols… Click to show full abstract
Diverse anti-Markovnikov hydrofunctionalization of alkenols triggered by the addition of S-, P-, and C-centered radicals to alkenes followed by intramolecular 1,5(6)-hydrogen atom transfer (HAT) with remote α-C–H bonds of alcohols has been developed. The strategy simultaneously realized the hydrofunctionalization of alkenes and remote alcohol oxidation. This mild and versatile method allows for direct access to valuable sulfonyl-, phosphonyl-, and malonate-substituted ketones or aldehydes from a wide range of alkenols.
Journal Title: Organic chemistry frontiers
Year Published: 2018
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