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γ-Lactone is an important scaffold found in many natural products and biologically active compounds. A strategy for one-pot bi-functionalization of unsaturated carboxylic acids to afford difluoroalkylated γ-lactones using a Cu(I)… Click to show full abstract
γ-Lactone is an important scaffold found in many natural products and biologically active compounds. A strategy for one-pot bi-functionalization of unsaturated carboxylic acids to afford difluoroalkylated γ-lactones using a Cu(I) catalyst has been reported. This protocol has the advantages of mild reaction conditions, a low-cost catalyst, and a broad substrate scope, which provides a convenient strategy for synthesizing various difluoroalkylated γ-lactones.
Keywords:
unsaturated carboxylic;
carboxylic acids;
catalyzed one;
one pot;
copper catalyzed
Journal Title: Organic chemistry frontiers
Year Published: 2018
Link to full text (if available)
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Journal Title: Organic chemistry frontiers
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!