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Visible-light-mediated allylation of alkyl radicals with allylic sulfones via a deaminative strategy

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A visible-light-mediated radical allylation of primary amine-derived Katritzky salts with allylic sulfones via C(sp3)–N bond activation is reported, furnishing the corresponding alkenes in satisfactory yields. This mild protocol provides an… Click to show full abstract

A visible-light-mediated radical allylation of primary amine-derived Katritzky salts with allylic sulfones via C(sp3)–N bond activation is reported, furnishing the corresponding alkenes in satisfactory yields. This mild protocol provides an efficient strategy for site-specific C(sp3)–C(sp3) bond formation using abundant feedstock primary amines, particularly α-amino acids as alkyl radical precursors. This photocatalytic reaction demonstrates a broad substrate scope and good functional group tolerance.

Keywords: light mediated; visible light; sulfones via; strategy; allylation; allylic sulfones

Journal Title: Organic chemistry frontiers
Year Published: 2018

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