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Dihydroxyindoles such as 5,6-dihydroxyindole-2-carboxylic acid (DHICA) are the main monomer units of eumelanin, the black to brown pigment in humans, and have emerging biological roles beyond melanin. Elaboration of commercially… Click to show full abstract
Dihydroxyindoles such as 5,6-dihydroxyindole-2-carboxylic acid (DHICA) are the main monomer units of eumelanin, the black to brown pigment in humans, and have emerging biological roles beyond melanin. Elaboration of commercially available 5,6-dimethoxy-2-carboxylate ethyl ester provides ready access to DHICA-inspired small molecules, including 3-(hetero)aryl-indoles and 4,7-di-(hetero)aryl-indoles.
Keywords:
ethyl ester;
expedient synthesis;
carboxylate ethyl
Journal Title: RSC Advances
Year Published: 2018
Link to full text (if available)
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Journal Title: RSC Advances
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!