"A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01074a"

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A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01074a

Steric bulk can compensate for a catalytically critical histidine in an intein's active site and promote the N–S acyl shift. Click to show full abstract

Steric bulk can compensate for a catalytically critical histidine in an intein's active site and promote the N–S acyl shift.

Keywords: interplay intein; histidine; extein sequences; functional interplay; intein extein; intein

Journal Title: Chemical Science
Year Published: 2019

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