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Asymmetric synthesis of (–)-naltrexone† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03748e

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The asymmetric synthesis of (–)-naltrexone was achieved by a Rh(i)-catalyzed C–H alkenylation and torquoselective electrocyclization cascade and late-stage C–H hydroxylation. Click to show full abstract

The asymmetric synthesis of (–)-naltrexone was achieved by a Rh(i)-catalyzed C–H alkenylation and torquoselective electrocyclization cascade and late-stage C–H hydroxylation.

Keywords: synthesis naltrexone; naltrexone electronic; electronic supplementary; asymmetric synthesis

Journal Title: Chemical Science
Year Published: 2019

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