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Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the… Click to show full abstract
Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.
Keywords:
polymer nanoparticles;
hybrid lipid;
sirna delivery;
lipid polymer
Journal Title: Biomaterials science
Year Published: 2020
Link to full text (if available)
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Journal Title: Biomaterials science
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!