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Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells.

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A novel approach to program target-responsive devices by incorporating the split G4 motifs in a DNA nanocage has been developed. The rigid prism outcompetes the flexible one in reaction kinetics… Click to show full abstract

A novel approach to program target-responsive devices by incorporating the split G4 motifs in a DNA nanocage has been developed. The rigid prism outcompetes the flexible one in reaction kinetics and signal/background ratios, which can be easily internalized by cells and successfully applied in microRNA imaging in live cells.

Keywords: imaging live; microrna imaging; live cells; split; dna nanocage

Journal Title: Chemical communications
Year Published: 2019

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