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Co(ii)/Cu(ii)-cocatalyzed oxidative C-H/N-H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones.

A cobalt and copper catalyzed reaction protocol has been developed to achieve the oxidative C-H/N-H annulation of benzamides containing an 8-aminoquinoline moiety as the directing group with ketones. Structurally diverse… Click to show full abstract

A cobalt and copper catalyzed reaction protocol has been developed to achieve the oxidative C-H/N-H annulation of benzamides containing an 8-aminoquinoline moiety as the directing group with ketones. Structurally diverse isoindolin-1-ones were furnished by the reaction of various substituent benzamides with ketones.

Keywords: oxidative functionalization; cocatalyzed oxidative; isoindolin ones; benzamides ketones; functionalization benzamides

Journal Title: Chemical communications
Year Published: 2019

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