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Fluorescence detection of glutathione S-transferases in a low GSH level environment.

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Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and the development of drug-resistance and are proved to be important markers for various tumors. Different from the previous probes,… Click to show full abstract

Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and the development of drug-resistance and are proved to be important markers for various tumors. Different from the previous probes, we developed a fluorescent probe enabling the detection of intracellular GSTs in a low GSH level environment by pre-treatment of the cells with thiol-scavengers.

Keywords: detection; low gsh; level environment; gsh level; glutathione transferases

Journal Title: Chemical communications
Year Published: 2019

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