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Construction of polycyclic bridged indene derivatives by a tandem 1,3-rearrangement/intramolecular Friedel-Crafts cyclization of propargyl acetates.

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An unprecedented Lewis acid-catalyzed cascade 1,3-rearrangement/Friedel-Crafts cyclization of propargyl acetates is developed for the construction of polycyclic bridged indene derivatives in moderate to good yields. This practical procedure features mild… Click to show full abstract

An unprecedented Lewis acid-catalyzed cascade 1,3-rearrangement/Friedel-Crafts cyclization of propargyl acetates is developed for the construction of polycyclic bridged indene derivatives in moderate to good yields. This practical procedure features mild conditions, broad substrate scope, and easy operation.

Keywords: crafts cyclization; construction polycyclic; cyclization propargyl; propargyl acetates; polycyclic bridged; friedel crafts

Journal Title: Chemical communications
Year Published: 2019

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